Author

T. A. Tummino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

B. K. Shoichet· 4 shared A. Alon· 2 shared A. I. Basbaum· 2 shared D. S. Radchenko· 2 shared H. R. O'Donnell· 2 shared J. J. Irwin· 2 shared J. Lyu· 2 shared J. M. Braz· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersPharmacology & Toxicology

B. K. Shoichet

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

T. A. Tummino, C. Iliopoulos-Tsoutsouvas, J. M. Braz, E. S. O'Brien, R. M. Stein, V. Craik, N. K. Tran, S. Ganapathy, F. Liu, Y. Shiimura, F. Tong, T. C. Ho, D. S. Radchenko, Y. S. Moroz, S. R. Rosado, , B. K. Shoichet

The paper identifies a new cannabinoid-1 receptor agonist with reduced side effects through large library docking and experimental validation.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens

H. R. O'Donnell, T. A. Tummino, C. Bardine, C. S. Craik, B. K. Shoichet

This study identifies colloidal aggregators in SARS-CoV-2 drug repurposing screens, showing that many drugs form colloids at therapeutic concentrations, potentially leading to false positive results.

bioRxiv · Aug 31, 2021Biochemistry

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

A. Alon, J. Lyu, J. M. Braz, T. A. Tummino, V. Craik, M. J. O'Meara, C. M. Webb, D. S. Radchenko, Y. S. Moroz, X.-P. Huang, Y. Liu, B. L. Roth, J. J. Irwin, A. I. Basbaum, B. K. Shoichet, A. C. Kruse

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

bioRxiv · Apr 29, 2021Pharmacology & Toxicology

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

T. A. Tummino, V. V. Rezelj, B. Fischer, A. Fischer, M. J. O'Meara, B. Monel, T. Vallet, Z. Zhang, A. Alon, H. R. O'Donnell, J. Lyu, H. Schadt, K. M. White, N. J. Krogan, L. Urban, , B. K. Shoichet

bioRxiv · Mar 23, 2021 · PreprintPharmacology & Toxicology