Author

H. R. VanDeusen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Assay:metabolomics· 1

Frequent Co-Authors

E. Potapenko· 2 shared H. R. Foster· 2 shared M. J. Merrins· 2 shared R. G. Kibbey· 2 shared R. L. Cardone· 2 shared S. L. Lewandowski· 2 shared T. Ho· 2 shared C. J. Thomas· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

E. Potapenko

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 9, 2022

The isoforms of pyruvate kinase act as nutrient sensors for the β-cell KATP channel

H. R. Foster, T. Ho, E. Potapenko…·M. J. Merrins

This study identifies PKm1 and PKm2 as nutrient sensors that regulate β-cell KATP channels through mitochondrial PEP, influencing insulin secretion and Ca2+ oscillations.

DOI 10.1101/2022.02.09.478817

mouseexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivJan 15, 2020

Pyruvate kinase controls signal strength in the insulin secretory pathway

S. L. Lewandowski, R. L. Cardone, H. R. Foster…·M. J. Merrins

This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.

DOI 10.1016/j.cmet.2020.10.007

mousemetabolomics

𝕏 PostBluesky