Author

R. L. Cardone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. G. Kibbey· 4 shared M. J. Merrins· 3 shared S. L. Lewandowski· 3 shared E. Potapenko· 2 shared H. R. Foster· 2 shared H. R. VanDeusen· 2 shared T. C. Alves· 2 shared T. Ho· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersPhysiology

R. G. Kibbey

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Author profile →

4 papers

Recent·Most cited

Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype

E. A. Davidson, Y. Chen, S. Singh, D. J. Orlicky, B. Thompson, Y. Wang, G. Charkoftaki, T. Furnary, R. L. Cardone, R. G. Kibbey, C. T. Shearn, D. W. Nebert, D. C. Thompson, V. Vasiliou

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

bioRxiv · Jun 13, 2023 · PreprintPhysiology

The isoforms of pyruvate kinase act as nutrient sensors for the β-cell KATP channel

H. R. Foster, T. Ho, E. Potapenko, S. M. Sdao, S. L. Lewandowski, H. R. VanDeusen, S. M. Davidson, R. L. Cardone, M. Prentki, R. G. Kibbey, M. J. Merrins

This study identifies PKm1 and PKm2 as nutrient sensors that regulate β-cell KATP channels through mitochondrial PEP, influencing insulin secretion and Ca2+ oscillations.

bioRxiv · Feb 9, 2022 · PreprintCell Biology

Pharmacologic activation of the mitochondrial phosphoenolpyruvate cycleenhances islet function in vivo

A. Abulizi, R. Stark, R. L. Cardone, S. L. Lewandowski, X. Zhao, T. C. Alves, C. Thomas, C. Kung, B. Wang, S. Siebel, Z. B. Andrews, M. J. Merrins, R. G. Kibbey

This study shows that pharmacologic activation of pyruvate kinase (PK) enhances insulin secretion in preclinical diabetes models by stimulating the mitochondrial phosphoenolpyruvate (PEP) cycle.

bioRxiv · Feb 13, 2020 · PreprintPhysiology

Pyruvate kinase controls signal strength in the insulin secretory pathway

S. L. Lewandowski, R. L. Cardone, H. R. Foster, T. Ho, E. Potapenko, C. Poudel, H. R. VanDeusen, T. C. Alves, X. Zhao, M. E. Capozzi, I. Jahan, C. S. Nunemaker, J. E. Campbell, C. J. Thomas, R. G. Kibbey, M. J. Merrins

This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.

bioRxiv · Jan 15, 2020Cell Biology