Author

H. S. Oshima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Iwama· 3 shared F. K. Sano· 3 shared H. Akasaka· 3 shared O. Nureki· 3 shared W. Shihoya· 3 shared A. Ogawa· 1 shared C. Nagiri· 1 shared F.-Y. Wei· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

A. Iwama

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural insights into the agonist selectivity and structure-based engineering of the adenosine A3 receptor

H. S. Oshima, A. Ogawa, F. K. Sano, H. Akasaka, T. Kawakami, H. H. Okamoto, A. Iwama, C. Nagiri, F.-Y. Wei, W. Shihoya, O. Nureki

The paper identifies a novel A3R-selective ligand and reveals structural insights into A3R activation, enabling structure-guided engineering of m6A-insensitive A3R for drug discovery.

bioRxiv · Mar 23, 2024 · PreprintBiophysics

Structure and dynamics of the RF-amide QRFP receptor GPR103

A. Iwama, H. Akasaka, F. K. Sano, H. S. Oshima, W. Shihoya, O. Nureki

This study reports the cryo-EM structure of the QRFP-GPR103-Gq complex, revealing unique binding mechanisms and insights into RF-amide peptide recognition.

bioRxiv · Dec 6, 2023 · PreprintBiochemistry

Optimizing Cryo-EM Structural Analysis of Gi-coupling Receptors via Engineered Gt and Nb35 Application

H. S. Oshima, F. K. Sano, H. Akasaka, A. Iwama, W. Shihoya, O. Nureki

The paper uses engineered G protein eGt with Nb35 to improve cryo-EM structure determination of GPCR-Gi complexes, achieving better map quality and reduced anisotropy.

bioRxiv · Oct 7, 2023 · PreprintBioengineering