A. Iwama

Structural insights into the agonist selectivity and structure-based engineering of the adenosine A3 receptor

The paper identifies a novel A3R-selective ligand and reveals structural insights into A3R activation, enabling structure-guided engineering of m6A-insensitive A3R for drug discovery.

Structure and dynamics of the RF-amide QRFP receptor GPR103

This study reports the cryo-EM structure of the QRFP-GPR103-Gq complex, revealing unique binding mechanisms and insights into RF-amide peptide recognition.

Optimizing Cryo-EM Structural Analysis of Gi-coupling Receptors via Engineered Gt and Nb35 Application

The paper uses engineered G protein eGt with Nb35 to improve cryo-EM structure determination of GPCR-Gi complexes, achieving better map quality and reduced anisotropy.

Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

This study identifies PRC1.1 as a regulator of homeostatic and emergency myelopoiesis, showing its role in balancing myeloid differentiation and preventing transformation.

Single-cell multi-omics analyses reveal EZH2 as a main driver of retinoic acid resistance in PLZF-RARA leukemia.

This study identifies EZH2 as a driver of retinoic acid resistance in PLZF-RARA leukemia using single-cell multi-omics analyses and shows targeting pan-EZH2 activities can eliminate resistant cells.

Stem cell therapy for skin regeneration using mesenchymal stem cells derived from the progeroid Werner syndrome-specific iPS cells

This study evaluates the efficacy of mesenchymal stem cells derived from Werner syndrome-induced pluripotent stem cells in treating skin ulcers, finding reduced angiogenic potential and improved healing with VEGF supplementation.