F. K. Sano

Structural insights into the agonist selectivity and structure-based engineering of the adenosine A3 receptor

The paper identifies a novel A3R-selective ligand and reveals structural insights into A3R activation, enabling structure-guided engineering of m6A-insensitive A3R for drug discovery.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.

Structure and dynamics of the RF-amide QRFP receptor GPR103

This study reports the cryo-EM structure of the QRFP-GPR103-Gq complex, revealing unique binding mechanisms and insights into RF-amide peptide recognition.

Optimizing Cryo-EM Structural Analysis of Gi-coupling Receptors via Engineered Gt and Nb35 Application

The paper uses engineered G protein eGt with Nb35 to improve cryo-EM structure determination of GPCR-Gi complexes, achieving better map quality and reduced anisotropy.

Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors

This study presents cryo-EM structures and experimental data revealing how beta-arrestins interact with GPCRs, particularly those with phosphorylation in the third intracellular loop and intrinsically biased receptors.

Structural basis for lysophosphatidylserine recognition by GPR34

This study presents cryo-EM structures of GPR34-Gi complex bound with LysoPS analogs, revealing ligand recognition mechanisms and identifying 2-acyl LysoPS as the physiological ligand.

Cryo-EM structure of the endothelin-1-ETB-Gi complex

The paper reports a cryo-EM structure of the endothelin-1-ETB-Gi complex, revealing structural changes upon G-protein activation and unique binding characteristics.