Steric Regulation of Tandem Calponin Homology Domain Actin-Binding Affinity
A. R. Harris, B. Belardi, P. Jreij, K. Wei, H. Shams, A. Bausch, D. A. Fletcher
The paper investigates how structural modifications affect the actin-binding affinity of tandem CH1-CH2 domains, finding that steric changes and interface mutations influence binding properties and sub-cellular localization.
bioRxiv · Oct 6, 2019Biochemistry