Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte
H. Zhang, N. N. Alder, W. Wang, H. Szeto, D. J. Marcinek, P. S. Rabinovitch
This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.
bioRxiv · Jan 2, 2020Cell Biology