D. J. Marcinek

Urolithin A induces cardioprotection and enhanced mitochondrial quality during natural aging and heart failure

This study shows that Urolithin A improves mitochondrial function and cardiac health in aging and heart failure models.

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

Evaluation of sex and age effects of fiber damage before permeabilization on mitochondrial respiration

This study evaluates how age, sex, and biopsy methods affect mitochondrial respiration in mouse muscle fibers and introduces a protocol to reduce variability.

Elamipretide (SS-31) Treatment Attenuates Age-Associated Post-Translational Modifications of Heart Proteins

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte

This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.