Author

N. N. Alder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

E. R. May· 2 shared H. H. Szeto· 2 shared W. Mitchell· 2 shared A. Alexandrescu· 1 shared A. Coscia· 1 shared D. J. Marcinek· 1 shared E. A. Ng· 1 shared E. Ng· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

E. R. May

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics

W. Mitchell, J. Tamucci, E. Ng, S. Liu, H. H. Szeto, E. R. May, A. Alexandrescu, N. N. Alder

This study analyzes structure-activity relationships of mitochondria-targeted tetrapeptides, finding that side chain composition and sequence register significantly affect their efficacy and membrane interactions.

bioRxiv · Nov 8, 2021 · PreprintBiochemistry

Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte

H. Zhang, N. N. Alder, W. Wang, H. Szeto, D. J. Marcinek, P. S. Rabinovitch

This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.

bioRxiv · Jan 2, 2020Cell Biology

Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions and Effects on Surface Electrostatics

W. Mitchell, E. A. Ng, J. D. Tamucci, K. Boyd, M. Sathappa, A. Coscia, M. Pan, X. Han, N. A. Eddy, E. R. May, H. H. Szeto, N. N. Alder

This paper investigates how SS-31 interacts with mitochondrial membranes, showing it modulates surface electrostatics and lipid packing, supporting its mitoprotective mechanism.

bioRxiv · Aug 14, 2019 · PreprintBiophysics