Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.
C. Chattopadhyay, R. Bhattacharya, J. Roszik, F. Khan, G. A. Wells, H. Villanueva, Y. Qin, R. Bhattacharya, S. Patel, E. A. Grimm
This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.
bioRxiv · Oct 26, 2022 · PreprintCell Biology