Y. Qin

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

Efficient and durable gene activation by Cas9-mediated epigenome editing in vivo

This paper demonstrates efficient and durable gene activation using Cas9-mediated epigenome editing in a mouse model of LAMA2-CMD, showing sustained therapeutic effects beyond one year.

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia

This study identifies aquaporins in endothelial cells that regulate microvascular diameter in hyperglycemia, suggesting they are potential targets for diabetes-related vascular therapy.

Efficient Gene Editing and Overexpression of Gametophyte Transformation in a Model Fern

This paper develops a CRISPR/Cas9 system for efficient gene editing and overexpression in the fern Ceratopteris richardii, demonstrating functional effects on stomatal and photosynthetic traits.

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Self-amplifying ROS-sensitive SN38 Dimeric Prodrug nanoparticles for Combined Chemotherapy and Ferroptosis in Cancer Treatment

This paper develops SN38-CA@FC NPs, a ROS-sensitive dimeric prodrug nanoparticle that combines chemotherapy and ferroptosis to treat cancer, showing potent antitumor activity in cell lines and mouse models.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma

This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.

Stomatal maturomics: identifying genes regulating guard cell maturation and function formation from single-cell transcriptomes

The paper identifies 586 genes up-regulated during stomata maturation using single-cell RNA-seq data and shows two TFs regulate guard cell size and function.

Data-driven optimization yielded a highly-efficient CRISPR/Cas9 system for gene editing in Arabidopsis

The paper develops a CRISPR/Cas9 system for Arabidopsis using the NUC1 promoter, achieving high editing efficiency and stable inheritance in the T2 generation.

PfAgo-based dual signal amplification biosensor for rapid and highly sensitive detection of alkaline phosphatase activity

This paper develops a PfAgo-based biosensor for detecting alkaline phosphatase activity with high sensitivity and rapid detection.

High red/far-red ratio promotes root colonization of Serratia plymuthica A21-4 in tomato by root exudates-stimulated chemotaxis and biofilm formation

Cryo-EM structure of TMEM63C suggests it functions as a monomer

The paper determines the cryo-EM structure of mouse TMEM63C, reveals structural differences from plant orthologues, and shows TMEM63C functions as a monomer while TMEM63B is a mix of monomer and dimer.

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

Molecular Evolution and Interaction of 14-3-3 Proteins with H+-ATPases in Plant Abiotic Stresses

This paper reviews the roles of 14-3-3 proteins and H+-ATPases in plant abiotic stress responses and analyzes their molecular evolution across species.

Hypoxia-induced circSTT3A maintains Breast Cancer Stem Cell formation by Stabilizing PGK1 protein

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

Substrate specificity and functional conservation of SWEET10 transporter in pineapple

This study examines the substrate specificity and functional conservation of the SWEET10 transporter in pineapple by comparing it to Arabidopsis SWEET8 and analyzing its role in microspore formation.

Design and characterization of porous poly(glycerol-dodecanedioate) scaffolds for cartilage repair

This paper develops porous PGD scaffolds for cartilage repair, showing they enhance ECM production and regulate hAC behavior through ligand coating and pore structure.

Transmembrane protein CD69 acts as an S1PR1 agonist

This study reveals that CD69 acts as a transmembrane protein agonist of S1PR1, promoting Gi-dependent internalization and inhibiting lymphocyte egress.

Perinuclear force regulates SUN2 dynamics and distribution on the nuclear envelope for proper nuclear mechanotransduction

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

CureSCi Metadata Catalog - Making sickle cell studies findable

The paper introduces a metadata catalog to enhance findability of sickle cell disease studies using FAIR principles through curated metadata and search tools.

Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.

This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.

Bone marrow AdipoQ-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis and bone mass

The paper identifies bone marrow AdipoQ-lineage progenitors as a major source of M-CSF, showing their critical role in macrophage development, osteoclastogenesis, and bone mass regulation.

Metallo-Supramolecular Branched Polymer Protects Particles from Air-water Interface in Single-Particle Cryo-Electron Microscopy

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.

Heterotrimeric G protein α subunit (GPA1) regulates the response to low-nitrogen stress in Arabidopsis by interacting with AtNRT1.4 and AtATG8a

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

Zinc arrests axonal transport and displaces tau, doublecortin, and MAP2C from microtubules

The paper shows Zn2+ inhibits axonal transport by binding microtubules and displacing tau, DCX, and MAP2C, affecting motor protein movement.

Electrical signature of heterogeneous human mesenchymal stem cells

This study uses dielectrophoresis to quantify heterogeneity in human mesenchymal stem cells and links electrical properties to differentiation potential.

Sulfite preservatives effects on the mouth microbiome: changes in viability, diversity and composition of microbiota

This study examines how sulfite preservatives affect saliva microbiota viability, diversity, and composition, finding significant changes in bacterial abundance and activity.