R. Bhattacharya

S-nitrosylation of EZH2 at C329 and C700 interplay with PRC2 complex assembly, methyltransferase activity, and EZH2 stability to regulate endothelial functions

Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma

The paper tests imipridones in a mouse model of uveal melanoma, finding they reduce tumor growth and improve survival by targeting oxidative phosphorylation.

Hippo effector, Yorkie, is a Tumor Suppressor in Select Drosophila Squamous Epithelia

This study shows that Yki signaling suppresses PI3K/Akt/TOR in Drosophila squamous epithelia, preventing tumor formation, and that its loss leads to cancer-like changes in multiple tubular organs.

Regulation of shelterin proteins TERF2IP and TRF2 by H3K4me3-p65 axis drives hyperglycemia dependent endothelial senescence

This study shows hyperglycemia increases TERF2IP and TRF2 via H3K4me3-p65 axis, driving endothelial senescence through p53 and p21 upregulation.

Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.

This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes

This study shows SARS-CoV-2 can infect kidney podocytes via ACE2 and BSG/CD147 receptors, causing cell death and foot process retraction, and suggests a stem cell model for drug screening.

Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells

The paper shows liver endothelial cells promote HER3-mediated survival in KRAS wild-type and mutant colorectal cancer cells through secreted factors, suggesting HER3 as a therapeutic target regardless of KRAS mutation status.

A Tensegrity-Graph Optimization Framework for Estimating Intracellular Stiffness

This paper introduces a tensegrity-graph framework to estimate intracellular stiffness by modeling cells as random graphs over dense nodes.

Understanding the Evolutionary Games in NSCLC Microenvironment

The paper uses evolutionary game theory to study non-cell autonomous resistance mechanisms in NSCLC, showing HGF-producing cells outcompete others and support therapy-naive cells.

High-throughput prediction of MHC Class I and Class II neoantigens with MHCnuggets

The paper introduces MHCnuggets, a deep learning method for predicting MHC class I and II neoantigen binding, showing improved performance and scalability across 26 cancer types.