Author

H.-D. Klenk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Salviato· 1 shared C. Rohde· 1 shared D. A. Stein· 1 shared D. Bestle· 1 shared E. Bottcher-Friebertshauser· 1 shared F. Bonfante· 1 shared G. Zamperin· 1 shared H. Limburg· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Salviato

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Characterization of changes in the hemagglutinin that accompanied the emergence of H3N2/1968 pandemic influenza viruses

J. West, J. Roeder, T. Matrosovich, J. Beicht, J. Baumann, N. Mounogou Kouassi, J. Doedt, N. Bovin, G. Zamperin, M. Gastaldelli, A. Salviato, F. Bonfante, S. Kosakovsky Pond, S. Herfst, R. Fouchier, , M. Matrosovich

The paper characterizes amino acid substitutions in the hemagglutinin of H3N2/1968 influenza viruses and their effects on receptor binding, stability, and replication.

bioRxiv · Apr 19, 2021Microbiology

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

D. Bestle, M. R. Heindl, H. Limburg, T. Van Lam van, O. Pilgram, H. Moulton, D. A. Stein, K. Hardes, M. Eickmann, O. Dolnik, C. Rohde, S. Becker, H.-D. Klenk, W. Garten, T. Steinmetzer, E. Bottcher-Friebertshauser

This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.

bioRxiv · Apr 15, 2020 · PreprintMicrobiology