Author

H. Moulton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. A. Stein· 2 shared A. Briley· 1 shared A. Garcia-Sastre· 1 shared B. R. Rosenberg· 1 shared C. Rohde· 1 shared C. Si· 1 shared D. Bestle· 1 shared D. Hawman· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

D. A. Stein

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Author profile →

3 papers

Recent·Most cited

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers.

K. Rosenke, S. Leventhal, H. Moulton, S. Hatlevig, D. Hawman, H. Feldmann, D. A. Stein

This study evaluates peptide-conjugated morpholino oligomers (PPMO) against SARS-CoV-2 in Vero cells, showing significant viral titer reduction without toxicity.

bioRxiv · Sep 29, 2020Microbiology

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

D. Bestle, M. R. Heindl, H. Limburg, T. Van Lam van, O. Pilgram, H. Moulton, D. A. Stein, K. Hardes, M. Eickmann, O. Dolnik, C. Rohde, S. Becker, H.-D. Klenk, W. Garten, T. Steinmetzer, E. Bottcher-Friebertshauser

This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.

bioRxiv · Apr 15, 2020 · PreprintMicrobiology

The regulatory factor ELF1 triggers a critical wave of transcription in the antiviral response to type I interferon

L. L. Seifert, C. Si, S. Ballentine, D. Saha, M. de Vries, G. Wang, M. Sadic, A. Briley, U. Schaefer, H. Moulton, A. Garcia-Sastre, S. Tripathi, B. R. Rosenberg, M. Dittmann

This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.

bioRxiv · Feb 14, 2019Immunology