Alteration in Gut Microbiome and Intestinal Barrier Function caused by Efavirenz versus Dolutegravir Treatments in Mice
Q. Tang, H.-e. Pan, Z. Liu, Z. Deng, Q.-Y. Zhong, H.-h. Cao, J.-y. Ye, J. Li, X.-y. Li, H.-p. Zhu, S. Chen
This study compares the effects of EFV and DTG on gut microbiome and intestinal barrier function in mice, finding both drugs impair gut barrier integrity, with EFV causing more severe metabolic and structural changes.
bioRxiv · Nov 1, 2023 · PreprintImmunology