S. Hussain

Triglyceride Polygenic Score Identifies Differential Bleeding and Cardiovascular Risk with Aspirin in Primary Prevention

This paper finds that a triglyceride-related polygenic score modifies aspirin's effects on bleeding and cardiovascular events in older adults, with different outcomes based on genetic risk profiles.

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

Identification of Alpha-Gal conjugated Lipids in Saliva of Lone-Star Tick (Amblyomma americanum)

This study identifies alpha-gal conjugated lipid antigens in Lone-Star tick saliva and shows their ability to activate basophils.

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer

This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

This study identifies LRRC23 as a critical component of the RS3 head in mammalian sperm, showing that its truncation leads to defective flagellar motility and male infertility.

The MYC axis in advanced prostate cancer is impacted through concurrent targeting of ERβ and AR using a novel ERβ-selective ligand alongside Enzalutamide

This study shows that combining a novel ERβ ligand with Enzalutamide reduces MYC signaling and growth in advanced prostate cancer.

DEVELOPMENT AND EVALUATION OF COATED RICOTTA CHEESE WITH WHEY PROTEIN AND CLOVE OIL

This study evaluates the effect of whey protein and clove oil coatings on ricotta cheese shelf life, finding that 0.75% whey protein and 0.3% clove oil significantly extended shelf life to 21 days.

Contribution of bacterial and host factors to pathogen "blooming" in a gnotobiotic mouse model for Salmonella enterica serovar Typhimurium-induced enterocolitis

This study investigates how bacterial and host factors contribute to Salmonella 'blooming' in a gnotobiotic mouse model of enterocolitis, showing that inflammation and specific Salmonella traits influence microbial community shifts and pathogen abundance.

Cholesterol-associated Locus EHBP1 Protects against NASH Fibrosis

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

Horizontally transferred genes as RNA interference targets for aphid and whitefly control

This study identifies horizontally transferred genes (HTGs) in aphids and whiteflies as potential RNAi targets for pest control, showing they can be silenced without harming beneficial insects.

Optical Metabolic Imaging Uncovers Sex- and Diet-dependent Lipid Changes in Aging Drosophila Brain

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

Influence of amino acids and glucosinolates in three Brassicaceae vegetable plants on preference and performance of the green peach aphid: Myzus persicae

This study examines how amino acids and glucosinolates in three Brassicaceae vegetables affect the preference and performance of the green peach aphid.

Emergence of new subgenomic mRNAs in SARS-CoV-2

This study identifies new subgenomic mRNAs in SARS-CoV-2 arising from mutations that create novel transcription regulatory sequences, leading to the expression of functional proteins like N.iORF3.

Vitamin D receptor cistrome-transcriptome analyses establishes quantitatively distinct receptor genomic interactions in African American prostate cancer regulated by BAZ1A

The paper analyzes VDR genomic interactions in African American prostate cancer cells and identifies BAZ1A as a regulator of VDR-dependent transcriptional responses.

Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection

This study compares SARS-CoV-2 infection outcomes in immunocompetent and immunocompromised hamsters, finding that histopathological changes better predict disease severity than viral load or antibody levels.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

Galectin-9 signaling drives breast cancer invasion through matrix

This study shows Galectin-9 promotes breast cancer invasion through ECM by enhancing S100A4 expression and FAK signaling.

The Effects of Prenatal Nicotine and THC E-Cigarette Exposure on Motor Development in Rats

This study examines how prenatal exposure to nicotine, THC, or their combination via e-cigarettes affects motor development in rat offspring, finding that combined exposure delays sensorimotor development and worsens motor coordination impairments, especially in females.

Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival

This study shows that blocking autophagy in skeletal muscles during sepsis worsens muscle dysfunction and reduces survival, suggesting autophagy is protective.

Pharmacokinetic Effects of Combined Exposure to Nicotine and THC via E-Cigarettes in Pregnant Rats

This study examines the physiological effects of combined nicotine and THC exposure via e-cigarettes in pregnant rats, finding altered drug levels and temperature changes.

Prenatal Alcohol and THC E-Cigarette Exposure Effects on Motor Development

This study examines the effects of prenatal alcohol and THC e-cigarette exposure on motor development in rats, finding delayed sensorimotor development from THC alone and hyperactivity from combined exposure.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

ST6GAL1-mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epithelia

This study identifies 2,6-linked sialic acid heterogeneity in breast cancer cells and shows that medium-expressing cells exhibit greater ECM adhesion and invasion compared to high-expressing cells, with ST6GAL1 playing a key role.

Response of Soil Microbiome Structure to Biological Control Agents (BCAs) in Strawberry Greenhouse

The paper investigates how biological control agents (BCAs) affect soil microbiome structure in strawberry greenhouses, finding increased bacterial diversity and potential inhibition of fungal pathogens.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses

This paper identifies a single amino acid change in the PA protein of H9N2 avian influenza viruses that enhances virulence and replication in poultry.