Dysregulated Alternative Splicing Landscape Identifies Intron Retention as a Hallmark and Spliceosome as a Therapeutic Vulnerability in Aggressive Prostate Cancer
D. Zhang, Q. Hu, Y. Ji, H.-P. Chao, A. Tracz, J. Kirk, S. Buonamici, P. Zhu, J. Wang, S. Liu, D. G. Tang
The paper identifies intron retention as a hallmark of aggressive prostate cancer and highlights the spliceosome as a therapeutic target by analyzing splicing dysregulation across prostate cancer progression.
bioRxiv · May 11, 2019 · PreprintCancer Biology