NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance
J.-M. Yang, Y. Ren, A. Kumar, X. Xiong, j. das, H.-y. Peng, L. Wang, X. Ren, R. C. Alainz, P. de Figueiredo, D. Fang, X. Liu, J. Wang, J. J. Song
This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.
bioRxiv · Mar 1, 2022Immunology