P. de Figueiredo

Infection of equine bronchial epithelial cells with a SARS-CoV-2 pseudovirus

This study shows equine bronchial epithelial cells can be infected by a SARS-CoV-2 pseudovirus, but with lower efficiency than human cells, likely due to lower ACE2 expression.

NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

A metabolically engineered bacterium controls autoimmunity by remodeling the pro-inflammatory microenvironment

A metabolically engineered bacterium produces indole to modulate macrophages and Tregs, reducing autoimmune arthritis by altering the pro-inflammatory microenvironment.

Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

Host protease activity on bacterial pathogens promotes complement- and antibiotic-directed killing

The paper shows host protease neutrophil elastase enhances complement- and antibiotic-mediated killing of bacterial pathogens by disrupting their evasion mechanisms.

Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes

This paper shows fungal hyaluronic acid interacts with host CD44 to recruit autophagy proteins to phagosomes, promoting fungal internalization via a Ca2+ -CaMKKβ-AMPK-ULK1 signaling pathway.

Sub-second heat inactivation of coronavirus

This paper develops a system to measure sub-second heat inactivation of coronavirus and identifies conditions achieving >5 Log10 viral titer reduction.

A tractable Drosophila cell system enables rapid identification of Acinetobacter baumannii host factors

This study uses Drosophila S2 cells to identify host factors and mechanisms involved in Acinetobacter baumannii intracellular survival and persistence.