X. Xiong

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation

This study shows that adding thiols to auranofin restores its anticancer activity by modulating albumin-gold binding and enhancing therapeutic efficacy.

A removable and cosmopolitan dsRNA Toti-like virus causes latent infection in a model diatom strain

The paper identifies a dsRNA Totiviridae virus in two diatom strains, shows it can be removed to create virus-free lines, and suggests it causes latent infection rather than lytic infection.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

Anti-adipogenic properties of clock activator chlorhexidine and a new derivative

This study identifies chlorhexidine and its derivative CM002 as clock activators with anti-adipogenic properties, showing they inhibit adipogenesis via Wnt pathway activation.

Emergent Antibiotic Persistence in Cross-Feeding Bacteria in Structured Habitats

This study shows that cross-feeding and spatial structure in bacterial communities can lead to increased antibiotic persistence in E. coli through 'dynamical loss of access to nutrient'.

Pervasive mislocalization of pathogenic coding variants underlying human disorders

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

Transcription repression of Cry2 via Per2 interaction promotes adipogenesis

This study identifies Cry2's role in adipogenesis through its interaction with Per2, showing that repression of Wnt signaling promotes adipocyte development.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

The clock-modulatory activity of Nobiletin suppresses adipogenesis via Wnt signaling

This study shows Nobiletin suppresses adipogenesis by enhancing the circadian clock and activating Wnt signaling, leading to reduced fat mass and body weight in mice.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Protease inhibitor ASP enhances freezing tolerance by inhibiting protein degradation in Kumquat

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

Actin cytoskeleton signaling via MRTF/SRF entrains circadian clock

This study shows that actin cytoskeleton signaling via MRTF/SRF modulates circadian clock entrainment by responding to extracellular matrix cues.

Circadian clock control of MRTF-SRF signaling suppresses beige adipocyte thermogenic recruitment

This study identifies a circadian clock control of MRTF-SRF signaling that suppresses beige adipocyte thermogenic recruitment and maintains metabolic homeostasis.

NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell- Mediated Tolerance

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii reveals novel virulence factors implicated in host cell invasion

ToxoNet constructs a high-confidence protein-protein interaction map for Toxoplasma gondii, identifying novel virulence factors involved in host cell invasion.

Toxoplasma infection alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease

This study investigates how Toxoplasma gondii infection affects dopamine-sensitive behaviors and gene expression in mice, revealing interactions between infection and cocaine exposure that may contribute to neuropsychiatric disorders.

Integrin signaling via actin cytoskeleton activates MRTF/SRF to entrain circadian clock

This study identifies an integrin-actin cytoskeleton-MRTF/SRF signaling cascade that modulates circadian clock properties by directly regulating core clock genes.

Invasive Earthworms Alter Forest Soil Microbiomes and Nitrogen Cycling

This study shows invasive earthworms alter soil microbiomes and shift nitrogen cycling from nitrification to denitrification in hardwood forests.

SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses

This study evaluates closed-state SARS-CoV-2 spike protein immunization in mice, finding it induces potent neutralizing antibodies and T-cell responses, with unique binding properties compared to standard S protein constructs.

Structural basis for broad coronavirus neutralization

This study identifies a monoclonal antibody that broadly neutralizes multiple beta-coronaviruses by targeting a conserved epitope, providing a structural basis for designing pan-coronavirus vaccines.

Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions

This study uses cryo-electron microscopy to determine the structure, conformational flexibility, and distribution of SARS-CoV-2 spike protein trimers on intact virions.

The native structure of the full-length, assembled influenza A virus matrix protein, M1.

This study determines the structure of assembled influenza A virus matrix protein M1 and reveals how it oligomerizes to mediate virion assembly and disassembly.

A thermostable, closed, SARS-CoV-2 spike protein trimer.

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+ supplementation

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.