Author

H.-Y. Yen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

C. V. Robinson· 2 shared A. Jazayeri· 1 shared A. Politis· 1 shared C.-C. Wu· 1 shared D. Wu· 1 shared E. Y. C. Mao· 1 shared F. Qu· 1 shared I. Liko· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

C. V. Robinson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

J. Toporowska, P. Kapoor, M. Musgaard, K. Gherbi, K. Sengmany, F. Qu, M. Soave, H.-Y. Yen, K. Hansen, A. Jazayeri, J. T. S. Hopper, A. Politis

This study uses HDX-MS to analyze structural dynamics of tβ1AR with different ligands, revealing ICL1 dynamics linked to GPCR activation and drug modality.

Nature Communications · Oct 18, 2024Peer-reviewedBiophysics

Structural Basis of How MGME1 Processes DNA 5' Ends to Maintain Mitochondrial Genome Integrity

E. Y. C. Mao, H.-Y. Yen, C.-C. Wu

This study determines the structural mechanism of MGME1's 5'-end DNA processing, revealing its bidirectional exonuclease activity and role in mtDNA maintenance.

bioRxiv · Jan 15, 2024Biochemistry

Correlating glycoforms of DC-SIGN with stability using a combination of enzymatic digestion and ion mobility MS

H.-Y. Yen, I. Liko, J. Gault, D. Wu, W. B. Struwe, C. V. Robinson

This study uses mass spectrometry to show that the stability of DC-SIGN is better correlated with the number of glycosylation sites than with glycan mass or length.

bioRxiv · Apr 22, 2020Biophysics

State-Dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

W. Song, H.-Y. Yen, C. V. Robinson, M. Sansom

This study uses MD simulations to show how specific lipids interact with the A2a receptor in different conformational states, revealing their role in regulating receptor function.

bioRxiv · Jul 6, 2018Biophysics