Rahul S. Kathayat

Reprogramming CAR T-Cells with designed bioPROTACs

This paper demonstrates that bioPROTACs can reprogram CAR T-cells by targeting DNMT3A, offering a tunable alternative to gene editing for enhancing T-cell function.

Acyl-protein thioesterase 1 (LYPLA1) activity promotes the growth of MDA-MB-468 triple-negative breast cancer cells.

This study identifies APT1/LYPLA1 as a context-dependent vulnerability in triple-negative breast cancer by showing its role in regulating cell proliferation through de-S-acylation of cell-cycle and mitochondrial proteins.

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.