Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells
Haiwei Zhang, Hongchen Li, Mingshun Lu, Shengnan Wang, Xueya Ma, Fei Wang, Jiaxi Liu, Xinyu Li, Haichao Yang, Fan Zhang, Haitao Shen, Noel J. Buckley, Nikita L. Gamper, Ebenezer N. Yamoah, Ping Lv
This study shows that REST deficiency leads to increased Kv7.4 channels in auditory neurons and hair cells, causing progressive hearing loss, which can be reversed by Kv7.4 inhibition.
eLife · Sep 20, 2022Peer-reviewedNeuroscience