Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer's disease pathology
Zhengrong Zhang, Hana Na, Qini Gan, Qiushan Tao, Yuriy O. Alekseyev, Junming Hu, Zili Yan, Jack B. Yang, Hua Tian, Shenyu Zhu, Qiang Li, Ibraheem M. Rajab, Jan Krzysztof Blusztajn, Benjamin L. Wolozin, Andrew Emili, , Wei Qiao Qiu
The paper shows that ApoE alleles compete with mCRP for CD31 binding on brain endothelia, leading to differential AD pathology based on ApoE genotype.
bioRxiv · May 30, 2021 · PreprintNeuroscience