Author

Junming Hu

Boston UniversityORCID 0000-0002-6503-7491Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 4 Neuroscience· 2 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 7 Organism:human· 7 Approach:statistical model· 7 Assay:bulk RNA-seq· 6 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Thor D. SteiniD· 6 shared Lindsay A. FarreriD· 5 shared Gyungah JuniD· 4 shared Rebecca PanitchiD· 4 shared Benjamin L. WoloziniD· 3 shared David Alan BennettiD· 3 shared Jaeyoon ChungiD· 3 shared Kathryn L. LunettaiD· 3 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Thor D. SteinORCID

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Author profile →

8 papers

Recent·Most cited

Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

Jenna Libera, Junming Hu, Tuyet-anh Nguyen, Zihan Wang, Sophie J. F. van der Spek, Kamryn Schult, Luke Dorrian, Jordan Majka, Katarnut Tobunluepop, Sambhavi Puri, Alexander Knyshov, Juao‐Guilherme S Rosa, Yuran Ma, Nicholas M. Kanaan, Peter T. Nelson, , Benjamin L. Wolozin

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

bioRxiv · May 2, 2025 · PreprintNeuroscience

Alzheimer Disease Heterogeneity Explained by Polygenic Risk Scores Derived from Brain Transcriptomic Profiles

Jaeyoon Chung, Nathan J Sahelijo, Toru Maruyama, Junming Hu, Rebecca Panitch, Weiming Xia, Jesse B Mez, Thor D. Stein, the Alzheimer's Disease Neuroimaging Initiative, Andrew J. Saykin, Haruko Takeyama, Lindsay A. Farrer, Paul K. Crane, Kwangsik T. Nho, Gyungah Jun

This study uses polygenic risk scores derived from brain transcriptomic profiles to explain clinical heterogeneity in Alzheimer's disease.

Alzheimer s & Dementia · May 11, 2023Peer-reviewedGenetic & Genomic Medicine

APOE Genotype-specific Methylation Patterns are Linked to Alzheimer Disease Pathology and Estrogen Response

Rebecca Panitch, Nathan J Sahelijo, Junming Hu, the Alzheimer’s Disease Neuroimaging Initiative, Kwangsik T. Nho, David Alan Bennett, Kathryn L. Lunetta, Rhoda Au, Thor D. Stein, Lindsay A. Farrer, Gyungah Jun

This study identifies APOE genotype-specific methylation patterns in blood and brain linked to Alzheimer's disease and estrogen response.

medRxiv · Dec 20, 2022 · PreprintGenetic & Genomic Medicine

Identification of circRNAs linked to Alzheimer's disease and related dementias

Sambhavi Puri, Junming Hu, Zhuorui Sun, Mintao Lin, Thor D. Stein, Lindsay A. Farrer, Benjamin L. Wolozin, Xiaoling Zhang

The paper identifies circRNAs associated with Alzheimer's disease and related dementias through transcriptome analysis and validates their expression in neuronal precursor cells exposed to oligomeric tau.

bioRxiv · Jul 13, 2022 · PreprintMolecular Biology

Protein phosphatase 2A, complement component 4, and APOE genotype linked to Alzheimer disease using a systems biology approach

Gyungah Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, David Alan Bennett, Tatiana Foroud, Weixin Wang, Jonathan L. Haines, Richard P Mayeux, Margaret Ann Pericak‐Vance, Gerard D. Schellenberg, , Lindsay A. Farrer

This paper identifies PPP2CB and C4B as key genes linked to Alzheimer's disease through a systems biology approach, showing their association with tau pathology and complement pathway activation.

Alzheimer s & Dementia · Feb 9, 2022Peer-reviewedGenetic & Genomic Medicine

Integrative Brain Transcriptome Analysis Links Complement Component 4 and HSPA2 to the APOE ε2 Protective Effect in Alzheimer Disease

Rebecca Panitch, Junming Hu, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David Alan Bennett, Kathryn L. Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D. Stein, Lindsay A. Farrer, Gyungah Jun

The paper identifies a co-expression network involving C4A, C4B, and HSPA2 linked to APOE ε2's protective effect against Alzheimer's disease, primarily associated with tau pathology.

Molecular Psychiatry · Sep 3, 2021Peer-reviewedGenetic & Genomic Medicine

Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer's disease pathology

Zhengrong Zhang, Hana Na, Qini Gan, Qiushan Tao, Yuriy O. Alekseyev, Junming Hu, Zili Yan, Jack B. Yang, Hua Tian, Shenyu Zhu, Qiang Li, Ibraheem M. Rajab, Jan Krzysztof Blusztajn, Benjamin L. Wolozin, Andrew Emili, , Wei Qiao Qiu

The paper shows that ApoE alleles compete with mCRP for CD31 binding on brain endothelia, leading to differential AD pathology based on ApoE genotype.

bioRxiv · May 30, 2021 · PreprintNeuroscience

scruff: An R/Bioconductor package for preprocessing single-cell RNA-sequencing data

Zhe Wang, Junming Hu, William Evan Johnson, Joshua David Campbell

scruff is an R/Bioconductor package that preprocesses scRNA-seq data from CEL-Seq protocols, providing quality metrics and visualizations for reproducible analysis.

BMC Bioinformatics · May 2, 2019Peer-reviewedBioinformatics