Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters
Mitsuhiro Matsuda, Hanako Hayashi, Jordi García‐Ojalvo, Kumiko Yoshioka-Kobayashi, Ryoichiro Kageyama, Yoshihiro Yamanaka, Makoto Ikeya, Junya Toguchida, Cantas Alev, Miki Ebisuya
Mouse and human segmentation clocks oscillate at 2-3 h and 5-6 h; slower HES7 degradation and longer delays in human cells, not sequence, explain it.
Science · Sep 17, 2020Peer-reviewedDevelopmental Biology✦ In-depth digest