Junya Toguchida

Modeling human limb skeletal development using human pluripotent stem cell-derived skeletal assembloids

This study develops a method to generate human skeletal assembloids that recapitulate limb skeletal development and endochondral ossification with longitudinal growth.

Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters

Mouse and human segmentation clocks oscillate at 2-3 h and 5-6 h; slower HES7 degradation and longer delays in human cells, not sequence, explain it.

Modeling the Human Segmentation Clock with Pluripotent Stem Cells

This study models the human segmentation clock using iPSC-derived presomitic mesoderm, identifying oscillatory genes and validating disease-related gene effects.