Mitsuhiro Matsuda

The paper identifies slower protein degradation in human cells compared to mice, linking protein stability differences to interspecies variations in developmental tempo.

This study investigates whether metabolic activities act as global modulators of the segmentation clock, finding they are selective modulators with varied effects on key processes.

The paper uses stem cell differentiation to study developmental tempo scaling across mammals and finds that segmentation clock periods correlate with phylogeny and biochemical kinetics of HES7, but not metabolic rates.

Mouse and human segmentation clocks oscillate at 2-3 h and 5-6 h; slower HES7 degradation and longer delays in human cells, not sequence, explain it.

This study models the human segmentation clock using iPSC-derived presomitic mesoderm, identifying oscillatory genes and validating disease-related gene effects.