Miki Ebisuya

This study induces skeletal muscle, neuronal, and endothelial cells from bovine embryonic stem cells and demonstrates their self-organization into vascularized tissue structures.

The paper identifies slower protein degradation in human cells compared to mice, linking protein stability differences to interspecies variations in developmental tempo.

This study develops an iPSC-based model with enhanced endothelial identity to study malaria parasite interactions and pathogenesis in vitro.

This study shows that altering lumen shape in human brain organoids affects apical progenitor division orientation and lineage progression.

This study identifies basal fluidization in human neuroepithelia as a tissue-level mechanism driving forebrain expansion, distinct from other great apes and mice.

The paper shows that glycolytic activity regulates germ layer proportions by modulating Nodal and Wnt signalling in mouse gastrulation.

This study investigates whether metabolic activities act as global modulators of the segmentation clock, finding they are selective modulators with varied effects on key processes.

The paper uses stem cell differentiation to study developmental tempo scaling across mammals and finds that segmentation clock periods correlate with phylogeny and biochemical kinetics of HES7, but not metabolic rates.

This paper introduces OptoShroom3, an optogenetic tool to control apical constriction in mammalian tissues, demonstrating its ability to induce 3D morphological changes in neural organoids.

Mouse and human segmentation clocks oscillate at 2-3 h and 5-6 h; slower HES7 degradation and longer delays in human cells, not sequence, explain it.

This study models the human segmentation clock using iPSC-derived presomitic mesoderm, identifying oscillatory genes and validating disease-related gene effects.

The paper demonstrates that a synthetic mammalian reaction-diffusion pattern can be generated using Nodal and Lefty proteins with differential diffusivity in cell culture.