Translational control of TFEB and autophagy via eIF5A rejuvenates B cell immunity
Hanlin Zhang, Ghada Alsaleh, Jack Feltham, Yizhe Sun, Thomas Riffelmacher, Philip Charles, Lisa Frau, Zhanru Yu, Shabaz Mohammed, Stefan Balabanov, Jane Mellor, Anna Katharina Simon
This study identifies a mechanism by which spermidine regulates autophagy through eIF5A-mediated TFEB translation, improving B cell immunity in aging.
bioRxiv · Dec 12, 2018 · PreprintCell Biology