Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels
Jack Feltham, Shidong Xi, Struan C. Murray, Meredith Wouters, Julian Urdiain‐Arraiza, Raphael Heilig, Charlotte L. George, Anna F. Townley, Emile Roberts, Benedikt Mathias Kessler, Sabrina Liberatori, Philip D. Charles, Andrew Angel, Román Fischer, Jane Mellor
The paper shows that transcriptional changes during biological rhythms do not directly affect protein levels, which remain constant due to slow turnover rates and post-translational regulation.
bioRxiv · Jun 10, 2020 · PreprintMolecular Biology