Anna Katharina Simon

Autophagy selectively clears ER in inflammation-induced muscle atrophy

This study reveals that autophagy selectively clears the endoplasmic reticulum during inflammation-induced muscle atrophy, challenging the classical view of atrophy as a uniform degradation process.

Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage

This study shows that rapamycin improves genome stability in aged human immune cells by reducing DNA damage, enhancing cell survival, and decreasing senescence markers.

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

This study shows that autophagy in adipocytes limits obesity-related fibrosis by controlling purine nucleoside metabolism and macrophage polarization.

Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I

This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic.