Jane Mellor

Metabolite accumulation mediates the shift between HOC and LOC phases in the Yeast Metabolic Cycle

The paper investigates the YMC phase transitions by integrating metabolic, chromatin, and transcriptional data, finding that metabolite accumulation mediates the shift between HOC and LOC phases.

Pharmacologically induced weight loss is associated with distinct gut microbiome changes in obese rats

This study examines how pharmacologically induced weight loss in obese rats affects their gut microbiome, identifying specific microbial taxa and pathways associated with weight loss.

Spt4 Facilitates the Movement of RNA Polymerase II through the +2 Nucleosomal Barrier

This study shows Spt4 regulates RNA polymerase II elongation and nucleosome positioning in yeast by facilitating movement through the +2 nucleosomal barrier.

FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

The paper identifies that FACT binds partially unwrapped nucleosomes in transcribed genes and spreads along genes in a Chd1-dependent manner.

Global and Gene-specific Transcriptional Responses to Acute Stress

The paper investigates the transcriptional response to acute stress in yeast, identifying two components: dynamic +1 nucleosome positioning and global Pol2 stalling leading to early transcription termination.

Single Nucleotide Resolution 4sU Sequencing (SNU-Seq) reveals the transcriptional responsiveness of an epigenetically primed human genome

This paper introduces SNU-Seq and sf4sU-Seq methods to map nascent transcripts at single-nucleotide resolution, revealing transcriptional responsiveness in an epigenetically primed human genome.

Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

The paper shows that cold exposure causes chromatin compaction and nuclear retention of circadian clock transcripts, which resets the circadian rhythm upon rewarming.

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

The paper shows that transcriptional changes during biological rhythms do not directly affect protein levels, which remain constant due to slow turnover rates and post-translational regulation.

H3K4me3 is neither instructive for, nor informed by, transcription.

The paper investigates the relationship between H3K4me3 and transcription, finding no direct instructive or informative link between the two on a genome-wide scale in budding yeast.

Translational control of TFEB and autophagy via eIF5A rejuvenates B cell immunity

This study identifies a mechanism by which spermidine regulates autophagy through eIF5A-mediated TFEB translation, improving B cell immunity in aging.

Antisense transcription-dependent chromatin signature modulates sense transcription and transcript dynamics

The paper shows antisense transcription affects sense transcript dynamics through a chromatin signature, with effects observed in yeast and human genes.

CRISPRi is not strand-specific and redefines the transcriptional landscape

This paper shows CRISPRi is not strand-specific and alters transcription by enabling both sense and antisense transcript generation.