The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity
Jan‐Kolja Strecker, Yannick Schmidt, Marie Liebmann, Carolin Walter, Stefan Roth, Hanna Aleth, Anna-Lena Börsch, Antje Schmidt‐Pogoda, Carolin Beuker, Ayan Mohamud Yusuf, Julian Revenstorff, Collins Osei-Sarpong, Lisa Krafft, Anna-Sophie Schwarze, Michael Heming, , Jens Minnerup
This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.
bioRxiv · Sep 19, 2025 · PreprintNeuroscience