Carlos Silvestre-Roig

This study shows NF-Y promotes myeloid cell survival and protects against inflammatory vascular disease by regulating transcriptional states in atherosclerosis.

This study identifies lamin A/C as a regulator of intestinal inflammation and tumorigenesis by modulating immune and stromal cell functions in mouse models and human IBD biopsies.

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

This study identifies CCR2+ neutrophils in atherosclerotic plaques that promote instability through ROS production and NET release, and shows that targeting CCR2 reduces plaque destabilization.

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.