Carolin Walter

T-Rex: Standardized Analysis of Germline Variants in Whole-Exome Sequencing Trios

T-Rex provides a standardized, no-programming-required tool for analyzing whole-exome sequencing trio data, achieving high precision and sensitivity in variant calling and filtering.

fourSynergy: Ensemble-based interaction calling on 4C-seq data using gradient-free optimization

fourSynergy combines multiple 4C-seq tools using gradient-free optimization to improve interaction calling performance across datasets.

The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

Microvascular immunity is organ-specific and concealed in peripheral blood

The paper analyzes microvascular immune cells in mouse organs and compares them to peripheral blood, finding organ-specific immune responses that are not detectable in blood or tissue samples.

PuMA: PubMed Gene-Celltype-Relation Atlas

PuMA extracts and visualizes gene-celltype relations from PubMed to aid in celltype annotation.

Clinical criteria for genetic testing in pediatric oncology show a low specificity and miss every 4th child carrying a cancer predisposition

The paper evaluates clinical checklists for genetic testing in pediatric oncology, finding low specificity and missing 25% of children with cancer predisposition variants.