Jan‐Kolja Strecker

This study shows that monocytes are essential for the neuroprotective effects of MSC-EVs in stroke, as their depletion negates these benefits and leads to immune system dysregulation.

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

The paper integrates single nuclei transcriptomics and spatial transcriptomics of human peripheral nerves to identify novel cell markers, reveal pan-nerve disease characteristics, and demonstrate potential for unbiased diagnostic classification.

This study shows NR4A1 reduces brain damage after ischemic stroke by limiting neutrophil activation and recruitment, with Cytosporone-B improving outcomes.

This paper reports a preclinical randomized trial showing that anti-IL-17A treatment reduces infarct volume in a mouse stroke model.