Attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor
Rebecca P. Sumner, Lucy Eke, Bruno Hernáez, Alasdair J. M. Hood, Telma Sancheira Freitas, Hannah Ashby, Ailish Ellis, Marine J. Petit, Sian Lant, Isobel Stokes, Preetam Parija, I. Alonso, Francisco Javier Alvarez-de Miranda, Alazne R. Unanue, Bryan Charleston, , Carlos Maluquer de Motes
This study compares a 2022 MPXV lineage B.1 virus with its clade IIb ancestor A.1, showing attenuated phenotypes including reduced virulence and immune evasion.
bioRxiv · Feb 27, 2025 · PreprintMicrobiology