Carlos Maluquer de Motes

The paper shows non-cyclic dinucleotide STING agonists effectively suppress MPXV infection by bypassing poxin-mediated inhibition, leading to reduced viral replication and improved survival in mice.

This study compares a 2022 MPXV lineage B.1 virus with its clade IIb ancestor A.1, showing attenuated phenotypes including reduced virulence and immune evasion.

This paper demonstrates that HIV-2/SIV Vpx antagonizes NF-κB activation by inhibiting p65 nuclear translocation, independent of known cofactors, and shows this mechanism is conserved across lentiviruses.

This study identifies SPSB1 as a negative regulator of NF-κB activation, showing its specificity for NF-κB and its role in inflammation and innate immunity.