Genome writing and Targeted Delivery of the NKX6-3/ANK1 gene cluster and its Type 2 Diabetes GWAS Variants to Human iPSCs
Noor Chalhoub, Arushi Varshney, Weimin Zhang, Skyler A. Uhl, Jon M. Laurent, Colleen Mcloughlin, Hannah Ashe, Xingrui Mou, Nathan Dale, Kiran Ramnarine, Daniel J Paull, Jordan Goldberg, Matthew T. Maurano, Ran Brosh, David Fenyö, , Jef D. Boeke
This paper introduces a method to deliver synthetic haplotypes containing T2D GWAS variants to hiPSCs to study their functional impact on differentiation.
bioRxiv · Jan 5, 2026 · PreprintGenetics