Jon M. Laurent

This study inserts a human RET haplotype into mice to model Hirschsprung disease, finding that regulatory variants reduce RET expression and contribute to disease.

This paper introduces a method to deliver synthetic haplotypes containing T2D GWAS variants to hiPSCs to study their functional impact on differentiation.

This paper introduces CREEPY, a method for efficiently editing large episomal DNA constructs in yeast, demonstrating its application to a mouse Sox2-harboring episome.

The paper introduces MERGE, a method for marker-less, scalable genome editing in yeast by combining CRISPR-Cas9 and gene drives to efficiently integrate and combine multiple genetic edits.

EUAdb is a database that standardizes information about FDA-authorized SARS-CoV-2 diagnostic tests to improve comparability and reproducibility.

The paper replaces yeast genes with human orthologs to study functional divergence, finding that replaceability depends on divergence and expression patterns of human co-orthologs.

The paper introduces a method to assemble synthetic haplotypes for functional analysis of AMD-associated variants, demonstrating its application to the 10q26 risk region.