Author

Xingrui Mou

Duke UniversityORCID 0000-0002-4258-672XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alekshyander Mishra· 1 shared Arushi VarshneyiD· 1 shared Christopher John SperatiiD· 1 shared Colleen Mcloughlin· 1 shared Daniel J PaulliD· 1 shared Daniel Silas· 1 shared David FenyöiD· 1 shared Douglas A. LauffenburgeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperGenetics

Alekshyander Mishra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Interactome-based deep learning and path-level decomposition reveal TGFβ-IFNα competition in MASH

Nikolaos Meimetis, Tyler Matsuzaki, Xingrui Mou, Lindsey Foster, Linda Gay Griffith, Douglas A. Lauffenburger

The paper uses a deep learning framework to analyze drug-induced transcriptomics and identifies a four-node module involved in TGFβ-IFNα competition in MASH.

bioRxiv · Oct 27, 2026 · PreprintSystems Biology

Genome writing and Targeted Delivery of the NKX6-3/ANK1 gene cluster and its Type 2 Diabetes GWAS Variants to Human iPSCs

Noor Chalhoub, Arushi Varshney, Weimin Zhang, Skyler A. Uhl, Jon M. Laurent, Colleen Mcloughlin, Hannah Ashe, Xingrui Mou, Nathan Dale, Kiran Ramnarine, Daniel J Paull, Jordan Goldberg, Matthew T. Maurano, Ran Brosh, David Fenyö, , Jef D. Boeke

This paper introduces a method to deliver synthetic haplotypes containing T2D GWAS variants to hiPSCs to study their functional impact on differentiation.

bioRxiv · Jan 5, 2026 · PreprintGenetics

A Novel TRPC6 Mutation Causes Autosomal Dominant FSGS

Rohan Bhattacharya, Xingrui Mou, Sophia M. Leeman, Alekshyander Mishra, Titilola D. Kalejaiye, Megan Stangl, Daniel Silas, Karen L. Soldano, Christopher John Sperati, Opeyemi A. Olabisi, Gentzon Hall, Samira Musah

The paper reports a novel TRPC6 mutation causing autosomal dominant FSGS and shows that combined Sildenafil and Losartan therapy improves podocyte dysfunction.

bioRxiv · Feb 11, 2025 · PreprintGenetics