A direct RPA-Polθ interaction licenses theta-mediated end joining
Marco Barazas, Celeste I. Bos, Hanneke Kool, Joost Schimmel, Robin van Schendel, Martijn S. Luijsterburg, Marcel Tijsterman
The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.
bioRxiv · Oct 27, 2026 · PreprintMolecular Biology