Marco Barazas

A direct RPA-Polθ interaction licenses theta-mediated end joining

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

CIP2A tetramerization is required for mitotic DNA repair

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis

MUSICiAn identifies DNA repair genes by analyzing mutational spectra from CRISPR-Cas9 perturbations without controls, revealing known genes and novel candidates.

Signatures in CRISPR Mutational Spectra Reveal Role and Interplay of Genes in DNA Repair

The paper uses CRISPR mutational spectra to identify functional roles of genes in DNA repair pathways by analyzing mutational signatures with non-negative matrix factorization.

Mutational signature catalogue (MUSIC) of DNA double-strand break repair

The paper constructs a mutational signature catalogue (MUSIC) by analyzing DSB repair gene knockouts, identifying gene clusters and novel roles in repair pathways.