Marcel Tijsterman

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

MUSICiAn identifies DNA repair genes by analyzing mutational spectra from CRISPR-Cas9 perturbations without controls, revealing known genes and novel candidates.

The paper uses CRISPR mutational spectra to identify functional roles of genes in DNA repair pathways by analyzing mutational signatures with non-negative matrix factorization.

This study uses long-read sequencing to analyze CRISPR-Cas9 editing outcomes and mosaicism in zebrafish, revealing genetic mosaicism in founder fish and its inheritance to offspring.

The paper constructs a mutational signature catalogue (MUSIC) by analyzing DSB repair gene knockouts, identifying gene clusters and novel roles in repair pathways.

The paper investigates how DNA repair genes influence Cas9-induced mutations by analyzing mutational outcomes across 2,838 synthetic targets in mouse cells, revealing gene-specific roles and improving predictive models.

The paper shows that DSBs in facultative heterochromatin require dUtx-mediated loss of H3K27me3 for repair by promoting DSB movement outside polycomb bodies.

SIQ is a tool for analyzing mutation profiles in sequencing data, identifying mutational signatures across different genetic backgrounds and supporting both Sanger and NGS data.

This study shows CRISPR-Cas9 induces structural variants and off-target mutations in zebrafish that persist through generations.

The paper shows that low-dose ionizing radiation stimulates insertional mutagenesis in a γH2AX-dependent manner in human and mouse cells.