Martijn S. Luijsterburg

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.

This study identifies resistance mechanisms and vulnerabilities to KIF18A inhibition in cancer cells using CRISPR screening and drug adaptation.

This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.

This study shows that PAF1C restores RNAPII elongation after DNA damage without requiring transcription-associated histone mark deposition.

This study identifies STK19 as a factor facilitating the transition from initial TCR complex assembly to downstream repair steps by enabling RNAPII clearance.

This study shows SMARCAD1 resolves R-loops at replication forks, preventing genome instability and cancer mutations.

This study identifies a selective RNAPII clearance defect in Cockayne syndrome cells, linking it to neurodegeneration rather than DNA repair failure.

This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.

VolcaNoseR is a web tool for creating, exploring, labeling, and sharing volcano plots from genome- and proteome-wide screens.

This study defines the sequential and cooperative assembly mechanism of the TCR complex and reveals how TFIIH is recruited to DNA damage-stalled RNAPIIo.