Robin van Schendel

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

MUSICiAn identifies DNA repair genes by analyzing mutational spectra from CRISPR-Cas9 perturbations without controls, revealing known genes and novel candidates.

The paper uses CRISPR mutational spectra to identify functional roles of genes in DNA repair pathways by analyzing mutational signatures with non-negative matrix factorization.

This study uses long-read sequencing to analyze CRISPR-Cas9 editing outcomes and mosaicism in zebrafish, revealing genetic mosaicism in founder fish and its inheritance to offspring.

The paper constructs a mutational signature catalogue (MUSIC) by analyzing DSB repair gene knockouts, identifying gene clusters and novel roles in repair pathways.

The paper shows that DSBs in facultative heterochromatin require dUtx-mediated loss of H3K27me3 for repair by promoting DSB movement outside polycomb bodies.

SIQ is a tool for analyzing mutation profiles in sequencing data, identifying mutational signatures across different genetic backgrounds and supporting both Sanger and NGS data.

This study shows CRISPR-Cas9 induces structural variants and off-target mutations in zebrafish that persist through generations.