Joost Schimmel

The paper identifies RPA as a critical factor for polymerase theta-mediated end joining and shows how RPA facilitates this process through a direct interaction with Polθ.

This study identifies TRIM28's role in pre-mRNA splicing through phosphorylation and SUMOylation interactions with USP39, showing its impact on alternative splicing patterns.

The paper investigates how DNA repair genes influence Cas9-induced mutations by analyzing mutational outcomes across 2,838 synthetic targets in mouse cells, revealing gene-specific roles and improving predictive models.

SIQ is a tool for analyzing mutation profiles in sequencing data, identifying mutational signatures across different genetic backgrounds and supporting both Sanger and NGS data.