Analyzing Presymptomatic Tissue to Gain Insights into the Molecular and Mechanistic Origins of Late-Onset Degenerative Trinucleotide Repeat Disease
Yongjun Chu, Jiaxin Hu, Hanquan Liang, Mohammed Kanchwala, Chao Xing, Walter E. Beebe, C. Bradley Bowman, Xin Gong, David R. Corey, V. Vinod Mootha
The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.
Nucleic Acids Research · May 11, 2020Peer-reviewedMolecular Biology